Thermo Fisher Scientific SCARB2 Monoclonal Antibody (1C8)
SCARB2 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, 인간 시료에 반응합니다. ELISA에 적합하며, 비결합(Unconjugated) 액상 형태로 제공됩니다. 친화 크로마토그래피로 정제되었으며, -20°C에서 보관 권장됩니다.
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Applications
ELISA (ELISA)
- Tested Dilution: 0.1 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1C8 |
| Immunogen | SCARB2 (NP_005497, 339 a.a. ~ 437 a.a) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein sequence:
FPHFYQADER FVSAIEGMHP NQEDHETFVD INPLTGIILK AAKRFQINIY VKKLDDFVET GDIRTMVFPV MYLNESVHID KETASRLKSM INTTLIITN
Target Information
High density lipoproteins (HDLs) play a critical role in cholesterol metabolism, and their plasma concentrations are inversely correlated with the risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are alternatively spliced products of a single gene.
SR-BII differs from SR-BI in that the encoded C-terminal cytoplasmic domain is almost completely different. SR-BII binds HDLs and mediates selective uptake of HDL cholesteryl ester, but with approximately 4-fold lower efficiency than SR-BI.
Nuclease protection assays show SR-BII to be abundant in mouse tissues expressing SR-BI, including liver, adrenal glands, and testes. Although the role of SR-BII is not completely clear, research suggests that it may function as an HDL receptor.
Additionally, SR-BII mRNA results from alternative splicing of SR-BI precursor transcripts, with the SR-BII isoform mediating selective lipid transfer between HDL and cells. The relative expression and functional activities of these two isoforms may regulate selective lipid transfer between HDL and cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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