Thermo Fisher Scientific Phospho-MARK Pan (Thr215) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

Antibody detects endogenous levels of MARK1/2/3/4 only when phosphorylated at Thr215.

Target Information

MARK1 (MAP/microtubule affinity-regulating kinase 1) belongs to the MARK family of serine/threonine kinases.
MARK family protein kinases phosphorylate microtubule-associated proteins and may play a role in cytoskeletal stability.
MARK2 refers to MAP/microtubule affinity-regulating kinase 2 isoform a (Homo sapiens).
EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubule stability, and cancer.
Several cDNA clones have been isolated that encode two isoforms of the human ser/thr protein kinase EMK1 called MARK2.
MARK3 was originally identified as a marker induced by DNA-damaging agents, and loss of MARK3 was found in pancreatic carcinogenesis.
MARK4 contains an N-terminal serine/threonine kinase domain, a central ubiquitin-associated domain, and a C-terminal KA1-associated kinase domain.
RT-PCR analysis detects upregulated expression of the gene for MARK4 in nearly all clinical hepatocellular carcinoma cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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