Thermo Fisher Scientific beta-2 Microglobulin Polyclonal Antibody
Rat beta-2 Microglobulin 단백질을 인식하는 Rabbit Polyclonal 항체. Western blot, IHC, ELISA에 적합하며, 보존제가 없는 고순도 액상 형태. 단백질 정제는 Protein A 및 항원 친화 크로마토그래피로 수행됨. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:10,000–1:50,000 |
| ELISA | 1:25,000–1:50,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Rat B2M/beta-2 microglobulin protein (Met1–Met119) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C (short term); -20°C (long term), avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2788785 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide (final concentration 0.05%–0.1%) to prevent contamination.
This antibody is specific for Rat B2M/beta-2 microglobulin.
Target Information
Beta-2-microglobulin (B2M) is a 12–14 kDa protein that forms part of the major histocompatibility complex (MHC) class I. It is expressed on various cell types including lymphocytes, monocytes, granulocytes, platelets, endothelial, and epithelial cells, but absent on erythrocytes.
B2M is homologous to immunoglobulin constant regions, primarily composed of beta-pleated sheets, and plays roles in antigen processing, presentation, and TCR signaling in naïve CD8+ cells.
The B2M gene is located on chromosome 15; mutations can cause hypercatabolic hypoproteinemia. Beta-2 microglobulin levels are used as renal function and HIV prognostic markers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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