Thermo Fisher Scientific SLC1A6 Polyclonal Antibody
SLC1A6 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, 인간·마우스·랫트 반응성. Western blot에 적합하며, 고순도 친화 크로마토그래피 정제. PBS 및 50% 글리세롤 보존, -20°C 저장.
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Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SLC1A6 (Accession P48664), corresponding to amino acid residues I514–M564 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2899789 |
Product Specific Information
Antibody detects endogenous levels of total EAAT4.
Target Information
Slc1a6 encodes a glutamate transporter protein, also known as excitatory amino acid transporter 4 (EAAT4). These transporters are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1), widely distributed throughout the brain.
There are five EAAT subtypes, each with specific distribution. SLC1A6 mediates uptake of L-glutamate, L-aspartate, and D-aspartate, functioning as a symporter transporting amino acids with Na(+) and H(+) ions, counter-transporting K(+) ions.
It also mediates Cl(-) flux to prevent negative charge accumulation. SLC1A6 plays a redundant role in rapid glutamate removal from the synaptic cleft, essential for terminating postsynaptic glutamate action.
Diseases associated with SLC1A6 include Dicarboxylic Aminoaciduria.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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