Thermo Fisher Scientific SLC1A6 Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:2,000

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total EAAT4.

Target Information

Slc1a6 encodes a glutamate transporter protein, also known as excitatory amino acid transporter 4 (EAAT4). These transporters are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1), widely distributed throughout the brain.
There are five EAAT subtypes, each with specific distribution. SLC1A6 mediates uptake of L-glutamate, L-aspartate, and D-aspartate, functioning as a symporter transporting amino acids with Na(+) and H(+) ions, counter-transporting K(+) ions.
It also mediates Cl(-) flux to prevent negative charge accumulation. SLC1A6 plays a redundant role in rapid glutamate removal from the synaptic cleft, essential for terminating postsynaptic glutamate action.
Diseases associated with SLC1A6 include Dicarboxylic Aminoaciduria.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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