Thermo Fisher Scientific EAAC1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000
• Publications: [참고 문헌 없음]

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total EAAT3.

Target Information

L-glutamate is the major excitatory neurotransmitter in mammalian central nervous systems. To maintain glutamate levels below excitotoxic levels, excess glutamate at excitatory synaptic clefts is removed by ion-coupled glutamate transporters.
Four glutamate transporters have been identified: sodium-dependent GLAST-1, GLT-1, EAAC-1, and chloride-dependent EAAT-4.
EAAC-1 is expressed in the CNS and also found in kidney and small intestine. Structural features of glutamate transporters include eight membrane-spanning α-helices and a loop-pore structure unique among secondary transporters, resembling loop-pores found in ion channels.
A second distinctive structural feature is a highly amphipathic membrane-spanning helix that provides a hydrophilic path through the membrane.
Mice with homozygous deletions of the EAAC-1 transporter gene develop dicarboxylic aminoaciduria and display reduced spontaneous locomotor activity, although no neurodegeneration was observed over 12 months.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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