Thermo Fisher Scientific Myelin Protein Zero/MPZ Monoclonal Antibody (MPZ/7390)
Myelin Protein Zero(MPZ)을 인식하는 mouse monoclonal antibody로, 인간 시료에 반응합니다. IHC(P)에서 1–2 µg/mL로 사용됩니다. 단백질 A/G로 정제된 액상 항체이며, PBS + 0.05% BSA 용액에 보존됩니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- 4359-MSM2-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Myelin Protein Zero/MPZ Monoclonal Antibody (MPZ/7390)
Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MPZ/7390 |
| Immunogen | Recombinant full-length human MPZ protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Peripheral nerve cells
- Cellular Location: Membrane
Target Information
Myelin Protein Zero (MPZ), also known as Zero, is a Type I integral membrane glycoprotein that mediates adhesion of spiraling wraps of the myelin sheath, ensuring stable synaptic transmission.
It constitutes approximately 50% of the total protein in the myelin sheath, contributing to structural integrity of peripheral myelin.
MPZ guides compact myelin wrapping through glycine zipper–dependent dimer and tetramer formation. Mutations such as G134R can disrupt multimerization, leading to demyelinating neuropathies including Charcot-Marie-Tooth disease.
The cytoplasmic domain undergoes serine and tyrosine phosphorylation, particularly during peak nerve myelination. MPZ transcript levels are moderate in the brain, abundant in the thymus, and highest in CNS white matter.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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