Thermo Fisher Scientific MRP1/ABCC1 (Multidrug Resistance Related Protein 1) Monoclonal Antibody (MRP1/1343)
인체 MRP1/ABCC1 단백질을 인식하는 단클론 항체로, Western blot, Flow cytometry, ELISA에 적합합니다. 단백질 A/G로 정제된 액상 형태이며, PBS(pH 7.4)에 보존제 없이 제공됩니다. 약물 내성 연구 및 ABC 수송체 연구에 유용합니다.
- 카탈로그번호
- 4363-MSM1-P1ABX
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MRP1/1343 |
| Immunogen | Recombinant full-length human ABCC1 protein (UniProt ID: P33527-1, length: 1531 aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The protein encoded by this gene belongs to the ATP-binding cassette (ABC) transporter superfamily, responsible for the translocation of various molecules across cellular membranes.
ABC proteins are categorized into seven subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
MRP1 (ABCC1) is part of the MRP subfamily, associated with multidrug resistance. It functions as a multispecific organic anion transporter, handling substrates such as oxidized glutathione, cysteinyl leukotrienes, and activated aflatoxin B1.
Additionally, it transports glucuronides and sulfate conjugates of steroid hormones and bile salts.
Alternative splicing by exon deletion results in multiple splice variants, all maintaining the original open reading frame.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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