Thermo Fisher Scientific RYBP Monoclonal Antibody (OTI1B6), TrueMAB
RYBP 단백질을 인식하는 Mouse monoclonal 항체로, Western blot 및 Flow cytometry에 적합합니다. Human 시료에 반응하며, Lyophilized 형태로 제공됩니다. Affinity chromatography로 정제되었으며, PBS buffer에 trehalose 포함. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Flow Cytometry (Flow)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B6 |
| Immunogen | Full length human recombinant protein of human RYBP produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of about 1 mg/mL.
- For conjugation experiments, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
RYBP is a component of the Polycomb group (PcG) multiprotein PRC1-like complex, which maintains the transcriptionally repressive state of various genes, including Hox genes, during development.
This complex mediates monoubiquitination of histone H2A at Lys-119, contributing to heritable chromatin modification.
RYBP may regulate TP53 stability and transcriptional activity, influence apoptosis through ubiquitination pathways, and function as a transcriptional repressor.
It may also play a role in tumor suppression and metastasis inhibition in breast cancer by down-regulating SRRM3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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