Thermo Fisher Scientific PIGR Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 15–20 µg/mL

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis:
Human, Gorilla (100%); Gibbon, Monkey (95%); Orangutan, Marmoset (89%).

Target Information

Polymeric IgA and IgM are produced and secreted by B cells in the lamina propria beneath the mucosal lining of polarized epithelial cells. Polymeric immunoglobulin receptors (pIgRs) are expressed on the basolateral surface of glandular epithelia and mediate the transcellular transport of secretory immunoglobulin polymers across the epithelium.

During this process, pIgR associates with secreted dimeric IgA and IgM molecules and undergoes proteolytic cleavage to generate a fragment called the secretory component (SC). When immunoglobulin polymers associate with SC, they gain resistance to enzymatic degradation during transcytosis. SC and pIgR are crucial for proper mucosal immunity, acting as molecular chaperones to maintain polymeric Igs intact for entry into body fluids.

The human SC (pIgR) gene maps to chromosome 1q31–q41 and encodes a 764-amino-acid protein containing five immunoglobulin variable (V)-like domains and a transmembrane region homologous to certain immunoglobulin variable regions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.