Thermo Fisher Scientific DYNLL1 Polyclonal Antibody
DYNLL1 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC, ELISA 등 다양한 응용에 적합. Human, Mouse, Rat 반응성. 고순도 Affinity Chromatography 정제, 액상 형태로 안정적 보관 가능. 연구용으로 세포 내 DYNLL1 위치 및 기능 분석에 유용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 1–89 of human DYNLL1 (NP_0037371) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.69 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet Ice |
| RRID | AB_2805810 |
Product Specific Information
- Immunogen sequence: MCDRKAVIKN ADMSEEMQQD SVECATQALE KYNIEKDIAA HIKKEFDKKY NPTWHCIVGR NFGSYVTHET KHFIYFYLGQ VAILLFKSG
- Positive Samples: HepG2, HeLa, A-549, 293T, NIH/3T3, Rat spinal cord
- Cellular Location: Cytoplasm, Mitochondrion, Nucleus, Cytoskeleton
Target Information
Cytoplasmic dyneins are large enzyme complexes (~1,200 kD) containing two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain with accessory intermediate chains. The complex is involved in intracellular transport and motility. DYNLL1 is a light chain component of this complex and interacts with neuronal nitric oxide synthase (nNOS), inhibiting its activity by destabilizing the dimeric form necessary for function. This interaction suggests DYNLL1 may regulate multiple biological processes through modulation of nitric oxide synthase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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