Thermo Fisher Scientific Beta-2 Microglobulin (Renal Failure and Tumor Marker) Monoclonal Antibody (246-E9.E7 (HLA.ABC.m2))
인간 반응성 마우스 IgG2a 카파 단클론 항체로, Beta-2 Microglobulin을 표적합니다. 신장 기능 평가 및 종양 마커 연구용으로 적합합니다. 단백질 A/G로 정제된 액상 형태이며, -20°C에서 보관합니다.
- 카탈로그번호
- 567-MSM1-P1ABX
- 판매단위
- pk
카탈로그
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 246-E9.E7 (HLA.ABC.m2) |
| Immunogen | Human peripheral blood lymphocytes (PBLs) from a T-cell acute lymphoblastic leukemia (T-ALL) patient |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Does not react with non-human primates.
Target Information
Beta-2-microglobulin (B2M) is a 12–14 kDa protein that forms part of the MHC class I complex. It is expressed on various human cells such as lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial and epithelial cells, but absent on erythrocytes.
It also exists freely in plasma and shares homology with the constant regions of immunoglobulin heavy and light chains, featuring a predominantly beta-pleated sheet structure.
B2M is involved in antigen processing and presentation, TCR signaling, and downstream signaling in naive CD8+ cells. It is encoded by the B2M gene on chromosome 15.
Mutations in this gene can lead to hypercatabolic hypoproteinemia.
Beta-2-microglobulin levels are useful for assessing renal function and as a prognostic marker in HIV infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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