Thermo Fisher Scientific MA2 Polyclonal Antibody
Thermo Fisher Scientific의 MA2 Polyclonal Antibody는 인간 PNMA2 단백질을 인식하는 토끼 다클론 항체로, Western blot 및 IHC(P) 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS 버퍼에 40% 글리세롤이 포함되어 안정적으로 보관 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PNMA2. Recombinant protein control fragment (Product # RP-102104) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.30 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2789156 |
Product Specific Information
Immunogen sequence:
KQENANAVLL ELLEDTDVSA IPSEVQGKGG VWKVIFKTPN QDTEFLERLN LFLEKEGQTV SGMFRALGQE GVSPATVPCI SPELLAHLLG QAMAHAPQPL LPMRYRKLRV FSGSAVPAPE EESFEVWLEQ ATEIVKEWPV TEAEKKRWL
Target Information
In patients with cancer, symptoms of limbic and brain-stem dysfunction may result from a paraneoplastic disorder. Two proteins, Ma1 and Ma2, were discovered by the presence of autoantibodies against them. Antibodies to Ma1 and Ma2 proteins identify a paraneoplastic disorder that affects the limbic system, brain stem, and cerebellum.
These autoantibodies were used to clone Ma2, which codes for a protein (Ma2) that was recognized by serum from the 10 patients, but not by serum from 344 control subjects. Ma2 was selectively expressed by normal brain tissue and by the testicular tumors of the patients. Ma2 shares homology with Ma1, a “brain-testis-cancer” gene related to other paraneoplastic syndromes and tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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