Thermo Fisher Scientific Phospho-CREB (Ser111) Polyclonal Antibody
CREB 단백질의 Ser111 인산화 상태를 특이적으로 검출하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC 등 다양한 응용에 적합. 인간, 마우스, 랫트 반응성. 고순도 액상 형태로 -20°C 보관.
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Thermo Fisher Scientific Phospho-CREB (Ser111) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CREB1 (Accession P16220), corresponding to amino acid residues around phosphorylated Ser111 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817244 |
Product Specific Information
Antibody detects endogenous levels of CREB only when phosphorylated at Ser111.
Target Information
CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to various extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors.
Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation occurs via p44/42 MAP kinase, p90RSK, p38 MAP kinase, and MSK1.
Although CREB binds DNA independent of phosphorylation, only the phosphorylated form functions as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator, interacts with CREB near serine 133.
CREB is involved in processes such as circadian rhythm synchronization, adipocyte differentiation, and learning and memory. In humans, the gene is located on the q arm of chromosome 2.
Diseases associated with CREB dysfunction include Alzheimer’s disease, histiocytoma, and soft tissue melanoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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