Thermo Fisher Scientific CABIN1 Monoclonal Antibody (2G2)

Applications

• Western Blot (WB): 1:500–1:1,000
• ELISA: 1:500–1:1,000

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MIRIAALNAS STIEDDHEGS FKSHKTQTKE AQEAEAFALY HKALDLQKHD RFEESAKAYH ELLEASLLRE AVSSGDEKEG LKHPGLILKY STYKNLAQLA AQREDLETAM

Target Information

Calcineurin binding protein (Cabin-1) and its rat homolog Cain are widely expressed nuclear phosphoproteins that regulate the serine/threonine phosphatase activity of calcineurin, influencing T cell signaling and apoptosis.
Calcineurin is required for the transcriptional activation of cytokines and transcription factors such as NFAT, NFκB, and AP-1 involved in TCR-mediated signaling.
TCR activation induces PKC-mediated hyperphosphorylation of Cabin-1, promoting high-affinity binding to calcineurin, which inhibits calcineurin activity and attenuates TCR signaling.
Cabin-1 also associates with MEF-2 transcription factors, inhibiting MEF-2-mediated gene transcription and apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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