Thermo Fisher Scientific CABIN1 Monoclonal Antibody (2F5)

Applications

• Western Blot (WB): 1:500–1:1,000
• ELISA: 1:500–1:1,000

Product Specifications

Product Specific Information

Sequence of this protein:
MIRIAALNAS STIEDDHEGS FKSHKTQTKE AQEAEAFALY HKALDLQKHD RFEESAKAYH ELLEASLLRE AVSSGDEKEG LKHPGLILKY STYKNLAQLA AQREDLETAM

Target Information

Calcineurin binding protein (Cabin-1) and its rat homolog Cain are widely expressed nuclear phosphoproteins that regulate the serine/threonine phosphatase activity of calcineurin and influence T cell signaling and apoptosis.

Calcineurin is required for cytokine transcriptional activation and activation of transcription factors such as NFAT, NFκB, and AP-1 involved in T cell receptor (TCR)-mediated signaling. Regulation of calcineurin depends on intracellular calcium concentration changes and protein kinase C (PKC) activity.

Upon TCR activation, PKC induces hyperphosphorylation of Cabin-1, enabling high-affinity binding to calcineurin. This complex inhibits calcineurin activity and attenuates TCR-mediated signaling. Cabin-1 also directly associates with MEF-2 proteins, transcription factors regulating apoptosis signaling in T cells, leading to inhibition of MEF-2-mediated gene transcription and apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.