Thermo Fisher Scientific FLT4 Monoclonal Antibody (4D1)

Applications

Western Blot (WB)

• Tested Dilution: 1–5 µg/mL

ELISA

• Tested Dilution: 1 ng/mL

Product Specifications

Product Specific Information

Sequence of this protein:

ITEESHVIDT GDSLSISCRG QHPLEWAWPG AQEAPATGDK DSEDTGVVRD 
CEGTDARPYC KVLLLHEVHA NDTGSYVCYY KYIKARIEGT TAASSYVFVR

Target Information

Vascular endothelial growth factor (VEGF) is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues. Unlike VEGF, the related VEGFC stimulates the growth of lymphatic vessels through its specific lymphatic endothelial receptor VEGFR-3.

In 1998, Dumont demonstrated that targeted inactivation of the VEGFR-3 gene in mice resulted in defective blood vessel development during early embryogenesis. Although vasculogenesis and angiogenesis occurred, large vessels became abnormally organized with defective lumens, leading to fluid accumulation in the pericardial cavity and cardiovascular failure at embryonic day 9.5. Thus, VEGFR-3 plays an essential role in embryonic cardiovascular development prior to the emergence of lymphatic vessels.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.