Thermo Fisher Scientific AKR1C2 Polyclonal Antibody
AKR1C2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western Blot, IHC, Flow Cytometry에 사용 가능. 인간, 생쥐, 랫트 반응성. 고순도(>95%) 항원 친화 크로마토그래피 정제. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 3 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Flow Cytometry (Flow) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 50–100 of human DD2 (AKR1C2, UniProt ID: P52895-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553592 |
Product Specific Information
- Detects endogenous protein at a molecular weight of 37 kDa
- Purity >95% by SDS-PAGE
Target Information
DD1 is also designated AKR1C1, DDH or DDH1, while DD2 can be designated AKR1C2, dDD, BABP or DDH2.
AKR1C3 and 3α-HSD are alternate designations for human DD3 (AKR1C18 in rodents), while DD4 can be called AKR1C4, CD, CHDR or AKR1C6 (in rodents).
DD1 and DD2 are 20α-HSDs, whereas DD3 and DD4 are 3α-HSDs.
Human cytosolic dihydrodiol dehydrogenases are involved in the metabolism of xenobiotics (polycyclic aromatic hydrocarbons, pesticides, steroid hormones) and reduction of ketone-containing drugs using NADH or NADPH as cofactors.
20α-HSD catalyzes the conversion of Progesterone to inactive 20α-hydroxyprogesterone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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