Thermo Fisher Scientific LOK Polyclonal Antibody
인간 STK10 단백질을 인식하는 Thermo Fisher Scientific의 LOK Polyclonal Antibody입니다. Western blot과 IHC(P)에서 검증되었으며, 항원 친화 크로마토그래피로 정제된 액상 항체입니다. 4°C 단기, -20°C 장기 보관 가능하며 연구용으로만 사용됩니다.
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Thermo Fisher Scientific LOK Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human STK10. Recombinant protein control fragment (Product #RP-91425). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789680 |
Product Specific Information
Immunogen sequence:
TLENHTQNSS EVSPPSLNAD KPLEESPSTP LAPSQSQDSV NEPCSQPSGD RSLQTTSPPV VAPGNENGLA VPVPLRKSRP VSMDARIQVA QEKQVAEQGG
Target Information
Ubiquitin exists either covalently attached to another protein or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues (polyubiquitin chains), or a linear polymer linked via the initiator Met (linear polyubiquitin chains).
Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue linked:
- Lys-6-linked: DNA repair
- Lys-11-linked: ERAD and cell-cycle regulation
- Lys-29-linked: lysosomal degradation
- Lys-33-linked: kinase modification
- Lys-48-linked: proteasomal degradation
- Lys-63-linked: endocytosis, DNA-damage response, NF-kappa-B activation
Linear polymer chains formed via attachment by the initiator Met lead to cell signaling.
Ubiquitin is usually conjugated to Lys residues of target proteins, but rare conjugation to Cys or Ser residues has been observed.
Free (unanchored) polyubiquitin also has distinct roles, such as activation of protein kinases and signaling.
60S ribosomal protein L40: Component of the 60S subunit of the ribosome. Essential for translation of a subset of cellular transcripts, especially for cap-dependent translation of vesicular stomatitis virus mRNAs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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