Thermo Fisher Scientific USP11 Polyclonal Antibody
Human USP11 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC, ICC/IF 등 다양한 응용에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS 버퍼에 40% 글리세롤 포함. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human USP11. Recombinant protein control fragment (Product #RP-92187). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789222 |
Product Specific Information
Immunogen sequence:
ESGRERPLRA GESWFLVEKH WYKQWEAYVQ GGDQDSSTFP GCINNATLFQ DEINWRLKEG LVEGEDYVLL PAAAWHYLVS WYGLEHGQPP IERKVIELPN IQKVEVYPVE LLLVRHNDLG KSHTVQFS
Target Information
USP11 (ubiquitin specific peptidase 11), also known as UHX1, is a 920 amino acid deubiquitinating enzyme that participates in the ubiquitin pathway. Localized to the nucleus, USP11 associates with both Ran BP-M (Ran binding protein M) and the tumor suppressor BRCA2. Through these associations, USP11 functions to inhibit ubiquitination or remove ubiquitin residues from these proteins. USP11 is implicated in several X-linked retinal diseases and may play a role in tumor suppression due to its ability to deubiquitinate BRCA2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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