Thermo Fisher Scientific SAP102 Polyclonal Antibody
SAP102 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC(F), ICC/IF에 적합합니다. 인간, 생쥐, 랫트 시료에 반응하며 항원 친화 크로마토그래피로 정제되었습니다. 단기 4°C, 장기 -20°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of Human SAP102 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.98 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2736555 |
Product Specific Information
- Positive Control: Mouse brain, Rat brain
- Predicted Reactivity: Human (100%), Rhesus Monkey (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Synapse-Associated Protein 102 (SAP102) is a plasma membrane-associated protein found in synaptic junctions. It contains three PDZ domains, an SH3 domain, and a Guanylate Kinase (GuK) domain. These domains are involved in receptor and channel clustering, contributing to neuronal plasticity. SAP102 participates in clustering NMDA receptors and shaker-type potassium channels at the synaptic membrane of CNS neurons. Other neuronal proteins sharing the T/SXV motif, such as β1 adrenergic receptor and certain serotonin receptors, may also interact with SAP102. Additionally, neuronal nitric oxide synthase (nNOS) associates with SAP102 via PDZ–PDZ domain interaction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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