Thermo Fisher Scientific Phospho-c-Myc (Ser293) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

Antibody detects endogenous levels of c-Myc only when phosphorylated at Ser293.

Target Information

The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays a crucial role in cellular proliferation, differentiation, apoptosis, and cell cycle progression.
Phosphorylation at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK has been linked to cell proliferation regulation.
c-Myc is essential for vasculogenesis and angiogenesis during tumor development. Deregulated expression of c-Myc can induce apoptosis in different cell types.
Antibodies against c-Myc epitopes recognize overexpressed proteins containing Myc epitope tags fused to amino or carboxy termini.
Amplification of c-Myc is observed in several human tumors (lung, breast, colon carcinomas), while N-Myc amplification is found in neuroblastomas.
Translocation of the c-Myc locus to immunoglobulin loci is characteristic of Burkitt’s lymphoma and other B-cell lymphoproliferative conditions.
Aberrant c-Myc expression occurs in tumors of diverse origins including colorectal, gastric, hepatic, mammary, ovarian, and hematopoietic neoplasms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.