Thermo Fisher Scientific IP6K2 Polyclonal Antibody
IP6K2 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 Immunocytochemistry에 적합. Human에 반응하며 Mouse, Rat 등에서도 예측 반응. 항원 친화 크로마토그래피로 정제된 액상 제품으로, 연구용으로만 사용 가능.
- 카탈로그번호
- PA528681
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 171–426 of Human IP6K2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.51 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2546157 |
Product Specific Information
- Predicted reactivity: Mouse (97%), Rat (97%), Xenopus laevis (82%), Rabbit (97%), Chicken (87%), Bovine (96%)
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
The members of the inositol hexakisphosphate kinase family, IP6K1 and IP6K2, have a high affinity and selectivity for inositol hexakisphosphate (InsP6) as a substrate.
IP6K1 and IP6K2 (also designated PiUS) convert InsP6 to PP-InsP5. Neither kinase demonstrates catalytic activity with other inositol pyrophosphates.
InsP6 inhibits serine/threonine protein phosphatases and increases calcium influx across the plasma membrane, suggesting a role in insulin exocytosis regulation.
IP6K1 was purified as a 54 kDa protein in rat brain extracts, and by homology, IP6K1 and IP6K2 were characterized in mouse as 50 kDa and 49 kDa proteins, respectively.
IP6K1 displays ATP synthase activity by transferring a phosphate from PP-InsP5 to ADP, indicating a potential role of IP6 kinases as high-energy phosphate donors.
주의사항
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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