Thermo Fisher Scientific TIAM2 Polyclonal Antibody
Human TIAM2 단백질에 특이적인 Rabbit Polyclonal Antibody로, IHC(P)와 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS buffer(40% glycerol 포함)에 보관. Rac1 활성화 관련 신호 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TIAM2. Recombinant protein control fragment (Product #RP-90642) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2648458 |
Product Specific Information
Immunogen sequence:
IKESDILSDE DDDHRQTVKQ GSPTKDIEIQ FQRLRISEDP DVHPEAEQQP GPESGEGQKG GEQPKLVRGH FCPIKRKANS TKRDRGTLLK AQIRHQSLDS QSENATIDLN SVL
Highest antigen sequence identity to the following orthologs:
- Mouse: 76%
- Rat: 72%
Target Information
TIAM2 modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities.
Acts as a GDP-dissociation stimulator protein that enhances GDP-GTP exchange activity of RHO-like GTPases, activating them.
Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth.
Involved in lamellipodial formation and advancement of the growth cone in embryonic hippocampal neurons.
Promotes migration of neurons in the cerebral cortex.
Overexpression induces membrane ruffling with actin filament accumulation along the altered plasma membrane.
Specifically activates RAC1, but not CDC42 or RHOA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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