Thermo Fisher Scientific Phospho-SYK (Tyr525) Polyclonal Antibody
SYK 단백질의 Tyr525 인산화 형태를 특이적으로 인식하는 rabbit polyclonal antibody. WB, IHC, ICC 등 다양한 응용에 적합하며, 인간 및 설치류에서 반응. 1 mg/mL 농도의 액상 형태로 제공되며, -20°C에서 보관.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | – |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | – |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | – |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SYK (Accession P43405), corresponding to amino acid residues around phosphorylated Tyr525. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816377 |
Product Specific Information
This antibody detects endogenous levels of SYK only when phosphorylated at Tyrosine 525.
Target Information
Spleen tyrosine kinase (SYK), along with ZAP70, are cytoplasmic tyrosine kinases that serve as potential drug targets for allergic disorders and autoimmune diseases. SYK may also play a role in cancer. Upon B cell antigen receptor (BCR) or high-affinity IgE receptor (FcεRI) activation, SYK translocates to the plasma membrane and phosphorylates downstream adaptor proteins, initiating signaling pathways such as calcium mobilization, cytoskeleton remodeling, and transcriptional activation. SYK binds receptor assemblies via its SH2 domains to ITAM motifs phosphorylated by Src-family kinases, which also activate SYK through phosphorylation of its activation loop.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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