Thermo Fisher Scientific CRTH2 Polyclonal Antibody

Applications

• Western Blot (WB): 1:100–1:2,000 dilution

Product Specifications

Product Specific Information

Suggested positive control: antigen standard for CRTC2 (transient overexpression lysate).

Target Information

CRTH2 (GPR44) is a chemoattractant receptor-homologous molecule expressed on Th2 cells and identified as a receptor for prostaglandin D2 (PGD2) and prostaglandin D receptor.
It mediates chemotaxis of Th2 cells and eosinophils to PGD2, playing a key role in allergic responses.
CRTH2-deficient mice exhibit enhanced eosinophil recruitment and increased IL-5 and IL-3 production, suggesting CRTH2 restricts eosinophilia and allergic responses in vivo.
This receptor is selectively expressed in Th2 lineage cells and found in the CNS, peripheral tissues, and blood cells, particularly activated Th2 cells.
Two transcripts have been identified:

• 3.5 kb transcript (thalamus, frontal cortex, pons, hippocampus)
• 3.4 kb transcript (fetal liver, leukocytes, thymus)

CRTH2 is involved in ongoing Th2-type immune reactions, and SNPs in its 3′ UTR are associated with asthma susceptibility.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음)