Thermo Fisher Scientific FBXW7 Polyclonal Antibody
FBXW7 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot에 최적화되어 있으며, 인간 시료에 반응. 항원 친화 크로마토그래피로 정제, 1 mg/mL 농도, PBS buffer에 sodium azide 포함. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB)
Tested Dilution: 1:100–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the N terminus of the 69 kDa isoform of the hCdc4 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153889 |
Product Specific Information
- Suggested positive control: antigen standard for FBXW7 (transient overexpression lysate)
Target Information
F-Box and WD Repeat Domain Containing 7 (FBXW7) is a member of the F-box protein family, characterized by an approximately 40 amino acid motif known as the F-box. These proteins form part of the SCF (SKP1-cullin-F-box) ubiquitin ligase complex, functioning in phosphorylation-dependent ubiquitination.
FBXW7 belongs to the Fbws class, containing WD40 domains and an F-box, and binds directly to cyclin E, targeting it for ubiquitin-mediated degradation. Mutations in FBXW7 are associated with ovarian and breast cancer cell lines, suggesting a role in tumor pathogenesis. Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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