Thermo Fisher Scientific ADAM17 Monoclonal Antibody (1F6)
ADAM17 단백질을 표적으로 하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (Clone 1F6). Western blot 및 ELISA에 적합하며, 인간 시료에 반응. 액상 형태, 비보존제 포함, -20°C 보관. 연구용으로만 사용 가능.
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- pk
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Thermo Fisher Scientific ADAM17 Monoclonal Antibody (1F6)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1F6 |
| Immunogen | ADAM17 (NP_003174.3, 215–314 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
RADPDPMKNT CKLLVVADHR FYRYMGRGEE STTTNYLIEL IDRVDDIYRN TSWDNAGFKG YGIQIEQIRI LKSPQEVKPG EKHYNMAKSY PNEEKDAWDV
Target Information
ADAM17 (disintegrin and metalloproteinase domain-containing protein 17) cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form.
It is responsible for the proteolytic release of soluble JAM3 from endothelial cell surfaces and other cell-surface proteins such as:
- p75 TNF-receptor
- Interleukin receptor type II
- p55 TNF-receptor
- Transforming growth factor-alpha
- L-selectin
- Growth hormone receptor
- MUC1
- Amyloid precursor protein
ADAM17 also acts as an activator of the Notch pathway by mediating cleavage of Notch and generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT).
Mutations in the gene can result in inflammatory skin and bowel disease, neonatal 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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