Thermo Fisher Scientific ADAM17 Monoclonal Antibody (1F6)

Thermo Fisher Scientific ADAM17 Monoclonal Antibody (1F6)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
RADPDPMKNT CKLLVVADHR FYRYMGRGEE STTTNYLIEL IDRVDDIYRN TSWDNAGFKG YGIQIEQIRI LKSPQEVKPG EKHYNMAKSY PNEEKDAWDV

Target Information

ADAM17 (disintegrin and metalloproteinase domain-containing protein 17) cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form.
It is responsible for the proteolytic release of soluble JAM3 from endothelial cell surfaces and other cell-surface proteins such as:

• p75 TNF-receptor
• Interleukin receptor type II
• p55 TNF-receptor
• Transforming growth factor-alpha
• L-selectin
• Growth hormone receptor
• MUC1
• Amyloid precursor protein

ADAM17 also acts as an activator of the Notch pathway by mediating cleavage of Notch and generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT).
Mutations in the gene can result in inflammatory skin and bowel disease, neonatal 1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.