Thermo Fisher Scientific ADAM17 Monoclonal Antibody (1F6)
인간 ADAM17 단백질을 인식하는 Mouse IgG2b 모노클로날 항체. Western Blot, IHC, ELISA 등 다양한 분석에 사용 가능. 친화 크로마토그래피로 정제된 액상 항체로, PBS(pH 7.4)에 보존제 없이 제공됨. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-Dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1F6 |
| Immunogen | ADAM17 (NP_003174.3, 215–314 a.a) partial recombinant protein with GST tag (MW of GST tag alone: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
RADPDPMKNT CKLLVVADHR FYRYMGRGEE STTTNYLIEL IDRVDDIYRN TSWDNAGFKG YGIQIEQIRI LKSPQEVKPG EKHYNMAKSY PNEEKDAWDV
Target Information
ADAM17 (disintegrin and metalloproteinase domain-containing protein 17) cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form.
It is responsible for the proteolytic release of soluble JAM3 from endothelial cell surfaces and several other cell-surface proteins, including p75 TNF-receptor, interleukin receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1, and amyloid precursor protein.
ADAM17 also acts as an activator of the Notch pathway by mediating cleavage of Notch and generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT).
Mutations in the ADAM17 gene can result in inflammatory skin and bowel disease, neonatal 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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