Thermo Fisher Scientific SLFN12 Polyclonal Antibody

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human SLFN12 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SLFN12,uniProtId:Q8IYM2-1,ncbiNodeId:9606,antigenRange:327-392,antigenLength:578,antigenImageFileName:PA5-54595_SLFN12_Q8IYM2-1_Rabbit.svg,antigenImageFileNamePDP:PA5-54595_SLFN12_Q8IYM2-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2647585

Product Specific Information

Immunogen sequence: NRVMQLTRKE WIQFMVEAEP KFSSSYEEVI SQINTSLPAP HSWPLLEWQR QRHHCPGLSG RITYTP

Highest antigen sequence identity to the following orthologs: Mouse - 30%, Rat - 29%.

Target Information

Despite being first described several years ago, the roles of the Schlafen (SLFN) family of proteins remain largely unknown. The SLFN genes are preferentially expressed in lymphoid tissues and differentially regulated during thymocyte maturation. It is thought that many play roles in cell growth, hemopoietic cell differentiation, and T cell development and maturation. Most members contain at least one divergent AAA domain (AAA_4) that may play a role in ATP binding. Although also known as SLFN3, a Schlafen family member that may be a marker of T cell activation, human SLFN12 has relatively low homology to SLFN3 in other species. Loss of the SLFN12 gene due to deletion is associated with Kabuki syndrome, a multiple congenital anomaly syndrome, suggesting SLFN may play a role in this genetic condition.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.