Thermo Fisher Scientific E-cadherin Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
• This antibody has specificity for Mouse E-Cadherin/CDH1.

Target Information

E-Cadherin (epithelial cadherin) is a classical cadherin belonging to the calcium-dependent adhesion protein superfamily. It is a cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail.
Mutations in this gene are associated with gastric, breast, colorectal, thyroid, and ovarian cancers. Loss of E-cadherin function promotes cancer progression by increasing proliferation, invasion, and metastasis.
The ectodomain mediates bacterial adhesion to mammalian cells, while the cytoplasmic domain is required for internalization.
E-cadherin plays a crucial role in tissue architecture and integrity. In humans, the CDH1 gene encoding E-cadherin is located on chromosome 16.
Reduced or lost E-cadherin expression in carcinomas correlates with increased invasiveness and metastatic potential.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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