Thermo Fisher Scientific E-cadherin Polyclonal Antibody
Thermo Fisher Scientific의 E-cadherin Polyclonal Antibody는 Mouse E-Cadherin/CDH1에 특이적입니다. WB, IHC, ELISA, IP 등 다양한 응용에 사용됩니다. 보존제가 없으며 고순도 Protein A 및 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| ELISA | 1:5,000–1:10,000 |
| Immunoprecipitation (IP) | 1–4 µL/mg of lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Mouse E-Cadherin/CDH1 protein (Met1–Val709) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2788605 |
Product Specific Information
- This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
- This antibody has specificity for Mouse E-Cadherin/CDH1.
Target Information
E-Cadherin (epithelial cadherin) is a classical cadherin belonging to the calcium-dependent adhesion protein superfamily. It is a cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail.
Mutations in this gene are associated with gastric, breast, colorectal, thyroid, and ovarian cancers. Loss of E-cadherin function promotes cancer progression by increasing proliferation, invasion, and metastasis.
The ectodomain mediates bacterial adhesion to mammalian cells, while the cytoplasmic domain is required for internalization.
E-cadherin plays a crucial role in tissue architecture and integrity. In humans, the CDH1 gene encoding E-cadherin is located on chromosome 16.
Reduced or lost E-cadherin expression in carcinomas correlates with increased invasiveness and metastatic potential.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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