Thermo Fisher Scientific p53AIP1 Polyclonal Antibody
Thermo Fisher Scientific의 p53AIP1 Polyclonal Antibody는 인간 p53AIP1 단백질을 인식하는 토끼 IgG 항체입니다. Western blot 및 Immunocytochemistry에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 PBS 버퍼에 0.02% sodium azide를 포함합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 4–8 µg/mL | View 1 publication |
| Immunocytochemistry (ICC/IF) | 10 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 15 amino acid peptide from near the amino terminus of human p53AIP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at –20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152385 |
Product Specific Information
- Suggested positive control: HL60 cell lysate
- PA5-20355 can be used with blocking peptide PEP-0475.
Target Information
The novel protein p53AIP1 (p53-regulated apoptosis-inducing protein 1) has been identified from direct cloning of p53 binding sequences from human genomic DNA. Expression of p53AIP1 in mitochondria is induced by wild-type p53, leading to apoptotic cell death through dissipation of mitochondrial potential.
Severe DNA damage causes phosphorylation of p53 at Ser-46, p53AIP1 expression, and apoptotic cell death. DNA damage-inducible apoptosis is enhanced through transcriptional activation of p53AIP1.
p53R2 is directly regulated by p53 to supply nucleotides for DNA repair, playing a key role in cell survival. Dysfunction of this pathway may activate p53-dependent apoptosis to eliminate damaged cells. Conversely, p53AIP1 mediates p53-dependent apoptosis, and phosphorylation of Ser46 regulates transcriptional activation of this apoptosis-inducing gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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