Thermo Fisher Scientific CD11b Monoclonal Antibody (ICRF44), Super Bright 436, eBioscience
인간 CD11b를 인식하는 ICRF44 단클론 항체로, Super Bright 436 형광체로 결합되어 Flow Cytometry에 최적화됨. 405 nm 레이저에서 여기, 436 nm에서 방출. 다양한 종에 교차 반응하며 세포 간 접착 연구에 활용 가능.
- 카탈로그번호
- 62-0118-4x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD11b Monoclonal Antibody (ICRF44), Super Bright 436, eBioscience
Thermo Fisher Scientific CD11b Monoclonal Antibody (ICRF44), Super Bright 436, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 1 publication |
| Flow Cytometry (Flow) | 5 µL (0.5 µg)/test | View 20 publications |
Product Specifications
| Specification | Description |
|---|---|
| Published species | Not Applicable |
| Host/Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Super Bright™ 436 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ICRF44 |
| Conjugate | Super Bright™ 436 |
| Excitation/Emission Max | 413/431 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Storage conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping conditions | Wet ice |
| RRID | AB_2662532 |
Available Formats
- Unconjugated
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Biotin
- Brilliant UV/Violet/Yellow series
- eFluor 506
- FITC
- NovaFluor Blue/Red/Violet/Yellow series
- PE, PE-Cyanine5, PE-Cyanine7, PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 600, 645, 702, 780
- Request custom conjugation available
Product Specific Information
The ICRF44 monoclonal antibody reacts with human CD11b, a 165 kDa adhesion molecule. CD11b, associated with integrin beta2 (CD18), is expressed on monocytes, granulocytes, activated lymphocytes, and a subset of NK cells. It serves as a receptor for ICAM family members (CD54, CD102, CD50) and iC3b, mediating crucial cell-cell and cell-matrix interactions.
This antibody crossreacts with baboon, chimpanzee, cynomologous monkey, and Rhesus macaque.
Reported applications: Flow cytometric analysis.
Tested applications: Pre-titrated for flow cytometry of human peripheral blood cells at 5 µL (0.5 µg)/test.
Super Bright 436 can be excited with a violet laser (405 nm) and emits at 436 nm. Recommended filter: 450/50 bandpass or equivalent.
When using multiple Super Bright dye-conjugated antibodies, use Super Bright Complete Staining Buffer (Product # SB-4401) to minimize non-specific polymer interactions.
Excitation: 405 nm
Emission: 436 nm
Laser: Violet Laser
Super Bright Polymer Dyes are sold under license from Becton, Dickinson and Company.
Target Information
CD11b (integrin alpha-M, ITGAM) forms a heterodimer with CD18, known as Mac-1 or CR3. It is expressed on monocytes/macrophages, granulocytes, activated lymphocytes, NK cells, dendritic cells, and microglia. Functions as receptor for ICAM-1, ICAM-2, ICAM-4, CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X.
Expression levels vary among tissues and increase during monocyte maturation. Commonly used as a microglial marker.
Associated diseases include systemic lupus erythematosus and ITGAM-related susceptibility to autoimmune disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.