Thermo Fisher Scientific Phospho-NOTCH3 (Ser84) Polyclonal Antibody
Phospho-NOTCH3 (Ser84) 특이적 폴리클로날 항체로, 인간, 생쥐, 랫트 시료에서 인산화된 NOTCH3 검출에 적합. Western blot 및 IHC(Paraffin) 적용 가능. 고순도 정제된 액상 형태로 안정적 저장 및 재현성 높은 결과 제공.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NOTCH3 (Accession Q9UM47), corresponding to amino acid residues around phosphorylated Ser84 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816751 |
Product Specific Information
Antibody detects endogenous levels of NOTCH3 only when phosphorylated at Ser84.
Target Information
NOTCH3 is the third discovered human homologue of the Drosophila melanogaster type I membrane protein notch. In Drosophila, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in neural development. Homologues of these ligands have also been identified in humans.
NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell-fate determination. Mutations in NOTCH3 are known to cause cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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