Thermo Fisher Scientific ZFP36 Polyclonal Antibody
ZFP36 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(Paraffin) 실험에 적합합니다. Human, Mouse, Rat에 반응하며, 1 mg/mL 농도의 액상 형태로 제공됩니다. Affinity chromatography로 정제되었으며, PBS와 50% glycerol에 보존됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ZFP36 (Accession P26651), corresponding to amino acid residues S52–S102 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2900709 |
Product Specific Information
This antibody detects endogenous levels of total Tristetraprolin.
Target Information
ZFP36 is a probable regulatory protein with a novel zinc finger structure involved in regulating the response to growth factors. Knockdown of ZFP36 increases both cognate macrophage gene mRNAs and inflammatory tumor necrosis factor protein release. Overexpression of ZFP36 decreases levels of the same genes, supporting its role in regulating macrophage gene expression. Multiple phosphorylation sites in ZFP36 in mammalian cells have been reported. ZFP36 can be phosphorylated by JNK as well as by other members of the MAP kinase family. Gene expression profiling predicts clinical outcome of prostate cancer. Inappropriate ZFP36 production may contribute to higher rheumatoid arthritis disease activity.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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