Thermo Fisher Scientific PIEZO1 Polyclonal Antibody
PIEZO1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, ICC/IF, ELISA에 적합하며 인간, 마우스, 랫트 반응성. 액상 형태로 고순도 친화 크로마토그래피 정제, -20°C 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 2230–2420 of human FAM38A/PIEZO1 (NP_0011363362) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.04 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2901628 |
Product Specific Information
- Positive Samples: U-87MG, LO2, MCF7
- Immunogen sequence:
PSIIPFTAQA YEELSRQFDP QPLAMQFISQ YSPEDIVTAQ IEGSSGALWR ISPPSRAQMK RELYNGTADI TLRFTWNFQR DLAKGGTVEY ANEKHMLALA PNSTARRQLA SLLEGTSDQS VVIPNLFPKY IRAPNGPEAN PVKQLQPNEE ADYLGVRIQL RREQGAGATG FLEWWVIELQ ECRTDCNLLP M
Target Information
Piezo1 is a pore-forming subunit of a mechanosensitive non-specific cation channel. It generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Structurally, Piezo1 contains 36 transmembrane domains and functions as a homotetramer.
Piezo1 plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER and subsequent stimulation of calpain signaling. In the kidney, Piezo1 may contribute to the detection of intraluminal pressure changes and urine flow sensing.
Piezo1 acts as a shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation, playing a key role in blood vessel formation and vascular structure in both development and adult physiology.
Defects in the PIEZO1 gene have been associated with dehydrated hereditary stomatocytosis and lymphedema.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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