Thermo Fisher Scientific SLFN11 Polyclonal Antibody
SLFN11 단백질을 인식하는 Rabbit Polyclonal Antibody로, 인간·마우스·랫트 반응성. WB, IHC, ICC/IF 등 다양한 응용 가능. DNA 손상 반응 및 항바이러스 연구에 적합. 1 mg/mL 액상, PBS+50% glycerol 보존.
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Thermo Fisher Scientific SLFN11 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human SLFN11 (Accession Q7Z7L1), residues I160–S210 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900554 |
Product Specific Information
Antibody detects endogenous levels of total SLFN11.
Target Information
SLFN11 acts as an inhibitor of DNA replication and promotes cell death in response to DNA damage. It functions as a guardian of the genome by eliminating cells with defective replication. SLFN11 blocks stressed replication forks by opening chromatin at replication initiation sites, potentially unwinding DNA ahead of the MCM helicase and halting fork progression, leading to cell death. It functions independently of ATR.
Additionally, SLFN11 serves as an interferon-induced antiviral protein that inhibits retrovirus protein synthesis, specifically suppressing production of viruses such as HIV-1 by targeting codon-usage-dependent viral protein synthesis. It binds tRNAs and exploits viral codon bias toward A/T nucleotides. The inhibition mechanism may involve tRNA sequestration, prevention of maturation, or acceleration of deacylation. SLFN11 does not inhibit reverse transcription, integration, or nuclear export of viral RNA.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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