Thermo Fisher Scientific Human ANG-2 Recombinant Protein, PeproTech
인간 ANG-2 재조합 단백질로 혈관내피세포의 tubulogenesis를 유도하는 기능을 검증함. CHO 세포에서 발현된 His-tag 단백질이며 순도 ≥95%. SDS-PAGE 및 HPLC 분석으로 확인된 고순도 단백질로 연구용 혈관신생 관련 실험에 적합.
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Applications
Functional Assay (Functional)
- Assay-dependent
In vitro Assay (IV)
- See related publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Published species | Human |
| Expression System | CHO cells |
| Amino acid sequence | DAPLEYDDSV QRLQVLENIM ENNTQWLMKL ENYIQDNMKK EMVEIQQNAV QNQTAVMIEI GTNLLNQTAE QTRKLTDVEA QVLNQTTRLE LQLLEHSLST NKLEKQILDQ TSEINKLQDK NSFLEKKVLA MEDKHIIQLQ SIKEEKDQLQ VLVSKQNSII EELEKKIVTA TVNNSVLQKQ QHDLMETVNN LLTMMSTSNS AKDPTVAKEE QISFRDCAEV FKSGHTTNGI YTLTFPNSTE EIKAYCDMEA GGGGWTIIQR REDGSVDFQR TWKEYKVGFG NPSGEYWLGN EFVSQLTNQQ RYVLKIHLKD WEGNEAYSLY EHFYLSSEEL NYRIHLKGLT GTAGKISSIS QPGNDFSTKD GDNDKCICKC SQMLTGGWWF DACGPSNLNG MYYPQRQNTN KFNGIKWYYW KGSGYSLKAT TMMIRPADFH HHHHH |
| Tag | His-tag |
| Molecular weight | 50.1 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥95% by SDS-PAGE gel and HPLC analyses |
| Endotoxin concentration | <1 EU/µg |
| Activity | Stimulates tubulogenesis in HUVEC cells at 0.2 µg/ml |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage conditions | -20°C |
| Shipping conditions | Ambient |
Product Specific Information
Recombinant Human ANG-2 is a C-terminal histidine-tagged glycoprotein which migrates with an apparent molecular mass of 60–70 kDa by SDS-PAGE under reducing conditions. Sequencing analysis shows an N-terminal sequence starting with residue 68 (D) of the ANG-2 precursor protein. The calculated molecular weight is 50.1 kDa.
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.
Target Information
ANG-2 binds to the endothelial cell-specific receptor Tie-2 but, unlike ANG-1, does not induce tyrosine phosphorylation. ANG-2 modulates ANG-1 activation of Tie-2 and may act as either an agonist or antagonist of Tie-2–induced angiogenesis depending on the environment.
The interactions among ANG-1, ANG-2, and Tie-2, along with ANG-3 and ANG-4, are essential for embryonic and adult angiogenesis. Physiologically, ANG-1 and ANG-2 are involved in sprouting, tube formation, and structural integrity of new blood vessels.
Mature human ANG-2 is a secreted protein containing 480 amino acid residues, composed of an α-helix-rich coiled coil N-terminal domain and a fibrinogen-like C-terminal domain. ANG-2 mainly exists as a disulfide-linked dimer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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