Thermo Fisher Scientific NOTCH2 Polyclonal Antibody

Thermo Fisher Scientific NOTCH2 Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 1:500–1:2,000
• Immunocytochemistry (ICC/IF): 1:50–1:200

Product Specifications

Product Specific Information

Purity is >95% by SDS-PAGE.

Target Information

Neurogenic locus notch homolog protein 2 (NOTCH2) is a highly conserved Notch signaling pathway protein.
NOTCH2 is a type I transmembrane protein with:

• Extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats
• Intracellular domain consisting of multiple, distinct domain types

NOTCH2 functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1, regulating cell-fate determination.
Defects in NOTCH2 cause Alagille syndrome type 2 (ALGS2), an autosomal dominant multisystem disorder characterized by:

• Hepatic bile duct paucity and cholestasis
• Cardiac, skeletal, and ophthalmologic manifestations
• Characteristic facial features
• Occasional renal and vascular involvement

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.