Thermo Fisher Scientific MYH9 Polyclonal Antibody
MYH9 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot, IHC, IP 등에 사용 가능. 인간, 마우스, 랫트 반응성. 고순도 (>95%) 항원 친화 크로마토그래피 정제. 연구용으로 세포 구조 및 혈구 관련 질환 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Immunoprecipitation (IP) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein of human MYH9 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803713 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
The MYH9 gene, located on chromosome 22q12.3, encodes the heavy chain of non-muscle myosin IIA (NMHC IIA), a crucial actin cytoskeleton component involved in cell migration, adhesion, division, and shape maintenance.
The gene spans over 106 kb with 41 exons encoding a 1,960 amino acid protein forming a hexameric complex (two heavy chains, two regulatory light chains, two essential light chains).
Mutations in MYH9 cause autosomal dominant MYH9-related diseases (MYH9-RD), such as May-Hegglin anomaly, Fechtner syndrome, and Epstein syndrome, characterized by macrothrombocytopenia and potential hearing loss, renal failure, and cataracts.
MYH9 is also vital in hematopoiesis, maintaining hematopoietic stem and progenitor cell survival; its dysfunction leads to blood cell deficiencies and bone marrow failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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