Thermo Fisher Scientific COX2 Polyclonal Antibody
COX2 단백질을 인식하는 고순도 Rabbit Polyclonal Antibody. Western blot 및 IHC(P) 실험에 최적화된 항체로 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제되었으며, 장기 보관 시 -20°C에서 안정적으로 유지.
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Thermo Fisher Scientific COX2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:4,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein of human COX2/PTGS2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803712 |
Product Specific Information
- Purity is >95% by SDS-PAGE.
Target Information
COX2 converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis, including production of inflammatory prostaglandins.
The conversion of arachidonate to prostaglandin H2 is a two-step reaction:
- A cyclooxygenase (COX) reaction converting arachidonate to prostaglandin G2 (PGG2).
- A peroxidase reaction reducing PGG2 to prostaglandin H2 (PGH2).
COX2 is constitutively expressed in certain tissues under physiological conditions (endothelium, kidney, brain) and up-regulated under pathological conditions such as cancer and inflammation.
Up-regulation of COX2 is associated with increased cell adhesion, phenotypic changes, resistance to apoptosis, and tumor angiogenesis.
In cancer cells, COX2 plays a key role in producing prostaglandin E2 (PGE2), which modulates motility, proliferation, and apoptosis resistance.
COX2 is naturally inhibited by calcitriol (active form of Vitamin D). Glucocorticoids repress PTGS2 gene activity in vivo by interfering with transcription processes.
COX2 is a target of NSAIDs such as aspirin, reducing pain and swelling caused by COX2-driven inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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