Thermo Fisher Scientific COX2 Polyclonal Antibody

Thermo Fisher Scientific COX2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Purity is >95% by SDS-PAGE.

Target Information

COX2 converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis, including production of inflammatory prostaglandins.
The conversion of arachidonate to prostaglandin H2 is a two-step reaction:

1. A cyclooxygenase (COX) reaction converting arachidonate to prostaglandin G2 (PGG2).
2. A peroxidase reaction reducing PGG2 to prostaglandin H2 (PGH2).

COX2 is constitutively expressed in certain tissues under physiological conditions (endothelium, kidney, brain) and up-regulated under pathological conditions such as cancer and inflammation.
Up-regulation of COX2 is associated with increased cell adhesion, phenotypic changes, resistance to apoptosis, and tumor angiogenesis.
In cancer cells, COX2 plays a key role in producing prostaglandin E2 (PGE2), which modulates motility, proliferation, and apoptosis resistance.
COX2 is naturally inhibited by calcitriol (active form of Vitamin D). Glucocorticoids repress PTGS2 gene activity in vivo by interfering with transcription processes.
COX2 is a target of NSAIDs such as aspirin, reducing pain and swelling caused by COX2-driven inflammation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.