Thermo Fisher Scientific P-Glycoprotein Polyclonal Antibody
P-Glycoprotein을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC, ELISA에 사용 가능. Human 및 Mouse 반응성. Affinity Chromatography로 정제된 액상 항체이며, 세포막 단백질 연구에 적합. -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein corresponding to amino acids 590–689 of human P-Glycoprotein (NP_000918.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.62 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804771 |
Product Specific Information
- Positive Samples: 293T, Mouse heart
- Cellular Location: Cell membrane, Multi-pass membrane protein
Immunogen sequence:
STVRNADVIA GFDDGVIVEK GNHDELMKEK GIYFKLVTMQ TAGNEVELEN AADESKSEID ALEMSSNDSR SSLIRKRSTR RSVRGSQAQD RKLSTKEALD
Target Information
The membrane-associated protein encoded by this gene belongs to the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport diverse molecules across cellular membranes and are divided into seven subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
This protein is part of the MDR/TAP subfamily, which is involved in multidrug resistance. It functions as an ATP-dependent drug efflux pump with broad substrate specificity, reducing drug accumulation in resistant cells and contributing to anticancer drug resistance. It also acts as a transporter in the blood-brain barrier.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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