Thermo Fisher Scientific Phospho-Ataxin 1 (Ser775) Polyclonal Antibody
Phospho-Ataxin 1 (Ser775) 폴리클로날 항체로, Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합합니다. Rabbit IgG 기반으로 Human, Mouse, Rat에 반응하며, Protein A 정제 및 고농도(1 mg/mL) 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human Ataxin 1 around the phosphorylation site of Ser776 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem, and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I–III.
ADCAI is genetically heterogeneous, with five genetic loci (SCA1, 2, 3, 4, and 6) assigned to different chromosomes. ADCAII, which presents with retinal degeneration (SCA7), and ADCAIII, often referred to as the “pure” cerebellar syndrome (SCA5), are likely homogeneous disorders.
Several SCA genes contain CAG repeats in their coding regions. Expansion of these repeats produces elongated polyglutamine tracts, leading to spinocerebellar ataxia type 1 (SCA1). The diseased allele contains 41–81 CAG repeats compared to 6–39 in the normal allele. This locus is mapped to chromosome 6. At least two transcript variants encoding the same protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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