Thermo Fisher Scientific Phospho-ATF2 (Ser480) Polyclonal Antibody
Phospho-ATF2 (Ser480) 폴리클로날 항체로, Western blot, IHC, ICC/IF, ELISA 등 다양한 응용에 적합합니다. Rabbit IgG 호스트에서 생산되었으며, Human 및 Mouse에 반응합니다. Protein A로 정제된 액상 형태로, 안정적인 신호 검출에 적합합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from mouse ATF2 around the phosphorylation site of Ser480 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The transcription factor ATF-2 (also called CRE-BP1) binds to both AP-1 and CRE DNA response elements and belongs to the ATF/CREB family of leucine zipper proteins.
ATF-2 interacts with various viral oncoproteins and cellular tumor suppressors and is a target of the SAPK/JNK and p38 MAP kinase signaling pathways.
Cellular stress, including genotoxic agents, inflammatory cytokines, and UV irradiation, stimulates ATF-2 transcriptional activity through phosphorylation at Thr69 and Thr71.
Both SAPK and p38 MAPK can phosphorylate ATF-2 at these sites in vitro and in transfected cells.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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