Thermo Fisher Scientific Phospho-ATF2 (Thr51, Thr53) Polyclonal Antibody
ATF2 단백질의 Thr51 및 Thr53 인산화 부위를 인식하는 Rabbit Polyclonal 항체로 인간, 마우스, 랫트 반응성을 가집니다. Western Blot, IHC, ICC/IF, ELISA 등 다양한 응용에 적합하며 Protein A로 정제된 고순도 항체입니다. -20°C에서 보관합니다.
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Thermo Fisher Scientific Phospho-ATF2 (Thr51, Thr53) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from mouse ATF2 around the phosphorylation site of Thr51 + Thr53 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The transcription factor ATF-2 (also called CRE-BP1) binds to both AP-1 and CRE DNA response elements and is a member of the ATF/CREB family of leucine zipper proteins.
ATF-2 interacts with various viral oncoproteins and cellular tumor suppressors and is a target of the SAPK/JNK and p38 MAP kinase signaling pathways.
Cellular stress, including genotoxic agents, inflammatory cytokines, and UV irradiation, stimulates ATF-2 transcriptional activity.
Activation occurs via phosphorylation at Thr69 and Thr71, mediated by SAPK and p38 MAPK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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