Thermo Fisher Scientific THPO Polyclonal Antibody, MaxPab

Applications

Tested Dilution

Publications

Western Blot (WB)

1-5 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

THPO (AAI30323.1, 1 a.a. approximately 349 a.a) full-length human protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Thrombopoietin,uniProtId:P40225-1,ncbiNodeId:9606,antigenRange:1-353,antigenLength:353,antigenImageFileName:H00007066-D01P_Thrombopoietin_P40225-1_Rabbit.svg,antigenImageFileNamePDP:H00007066-D01P_Thrombopoietin_P40225-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MELTELLLVV MLLLTARLTL SSPAPPACDL RVLSKLLRDS HVLHSRLSQC PEVHPLPTPV LLPAVDFSLG EWKTQMEETK AQDILGAVTL LLEGVMAARG QLGPTCLSSL LGQLSGQVRL LLGALQSLLG TQGRTTAHKD PNAIFLSFQH LLRGKVRFLM LVGGSTLCVR RAPPTTAVPS RTSLVLTLNE LPNRTSGLLE TNFTASARTT GSGLLKWQQG FRAKIPGLLN QTSRSLDQIP GYLNRIHELL NGTRGLFPGP SRRTLGAPDI SSGTSDTGSL PPNLQPGYSP SPTHPPTGQY TLFPLPPTLP TPVVQLHPLL PDPSAPTPTP TSPLLNTSYT HSQNLSQEG

Target Information

Thrombopoietin (TPO, THPO, MPL ligand, megakaryocyte colony-stimulating factor) is responsible for the generation of platelets through its action on hematopoietic cells committed to the megakaryocyte lineage. Binding of thrombopoietin to its receptor, MPL (CD110), initiates a signaling cascade via JAK/STAT, MAPK, and PI3K/AKT signaling pathways that leads to the proliferation and differentiation of megakaryocytes and, ultimately, to the production of platelets (thrombopoiesis). Thrombopoietin is constitutively produced by the liver and has a predicted molecular weight of 38 kDa.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.