Thermo Fisher Scientific KLF10 Monoclonal Antibody (4G9)
KLF10 단백질을 인식하는 Mouse IgG2b monoclonal antibody로 Western blot, ICC/IF, ELISA에 사용 가능. 인간 시료 반응성. Affinity chromatography로 정제된 액상 형태. 연구용으로 TGF-beta 신호 및 세포 성장 조절 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4G9 |
| Immunogen | KLF10 (AAH11538.1, 1–110 a.a) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MEERMEMISE RPKESMYSWN KTAEKSDFEA VEALMSMSCS WKSDFKKYVE NRPVTPVSDL SEEENLLPGT PDFHTIPAFC LTPPYSPSDF EPSQVSNLMA PAPSTVHFKS
Target Information
KLF10 is a nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family with three C2H2-type zinc fingers. It acts as a transcriptional repressor involved in regulating cell growth and apoptosis. KLF10 binds to the consensus sequence 5’-GGTGTG-3’ and is induced by TGF-beta, linking TGF-beta signaling to pancreatic epithelial cell growth regulation. It may inhibit Smad7 expression and is ubiquitously expressed in most tissues. Overexpression has been associated with renal clear cell carcinoma and other tumors.
KLF11, a related zinc finger transcription factor, binds SP1-like sequences and inhibits cell growth, potentially causing apoptosis. Defects in KLF11 are linked to maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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