Thermo Fisher Scientific RYBP Monoclonal Antibody (OTI4E10), TrueMAB
RYBP 단백질을 인식하는 마우스 단일클론 항체로, Western blot 및 Immunocytochemistry에 적합. 인간 시료 반응성, carrier-free 제형으로 재결정 및 결합 실험에 활용 가능. PRC1 복합체 관련 연구용으로 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4E10 |
| Immunogen | Full-length human recombinant RYBP protein produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
RYBP is a component of the Polycomb group (PcG) PRC1-like complex, which maintains transcriptional repression of genes such as Hox throughout development.
This complex mediates monoubiquitination of histone H2A (Lys-119), influencing chromatin remodeling and gene expression.
RYBP contributes to X-chromosome silencing in females, regulates TP53 stability by inhibiting its ubiquitination, and may influence apoptosis through degradation control of proteins like FANK1.
It may also act as a transcriptional repressor and play a role in tumor suppression, particularly in breast cancer by down-regulating SRRM3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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