Thermo Fisher Scientific ITM2B Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 1:500

Product Specifications

Product Specific Information

PA1-25724 detects ITM2B from human, mouse, and rat samples.

Target Information

Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides, which form the characteristic plaques of Alzheimer’s disease.
This gene encodes a transmembrane protein processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide that inhibits beta-amyloid deposition.
Mutations extending the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurodegenerative diseases: familial British dementia and familial Danish dementia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.