Thermo Fisher Scientific ITM2B Polyclonal Antibody
ITM2B 단백질을 인식하는 Thermo Fisher Scientific의 다클론 항체로, 인간·마우스·랫 시료에서 사용 가능. Western blot에 적합하며 1:500 희석 권장. 액상 형태로 제공되며 단기 4°C, 장기 -20°C 보관. 알츠하이머 및 신경퇴행성 질환 연구에 활용.
- 판매단위
- pk
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Applications
- Western Blot (WB): Tested dilution 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Chicken / IgY |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 1–60 of ITM2B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2249423 |
Product Specific Information
PA1-25724 detects ITM2B from human, mouse, and rat samples.
Target Information
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides, which form the characteristic plaques of Alzheimer’s disease.
This gene encodes a transmembrane protein processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide that inhibits beta-amyloid deposition.
Mutations extending the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurodegenerative diseases: familial British dementia and familial Danish dementia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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