Thermo Fisher Scientific CD86 Monoclonal Antibody (1B3)

Thermo Fisher Scientific CD86 Monoclonal Antibody (1B3)

Applications and Tested Dilution

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Product Specifications

Product Specific Information

MA5-15697 targets CD86 in indirect ELISA and WB applications, showing reactivity with Human samples.
The immunogen is a purified recombinant fragment of human CD86 expressed in E. coli.
MA5-15697 detects CD86 with a predicted molecular weight of approximately 52 kDa.

Target Information

CD86 is one of two ligands (the other being CD80) for CTLA4 and CD28. It acts as a costimulatory molecule in eliciting T-cell help during antigen presentation.
Antigen presentation without sufficient co-stimulation involving CD86/CD80 can induce tolerance.
CD86 is a type I membrane protein and a member of the immunoglobulin superfamily. It is expressed by antigen-presenting cells and serves as a ligand for CD28 antigen and cytotoxic T-lymphocyte-associated protein 4 (CTLA4) on T cells.
Binding with CD28 provides a costimulatory signal for T-cell activation, while binding with CTLA4 negatively regulates T-cell activation and diminishes the immune response.
Alternative splicing results in two transcript variants encoding different isoforms of CD86. Additional transcript variants have been described, but their full-length sequences have not been determined.
Diseases associated with CD86 dysfunction include gallbladder squamous cell carcinoma and myocarditis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.