Thermo Fisher Scientific EGF Monoclonal Antibody (10827)
EGF 단백질을 특이적으로 인식하는 마우스 단클론 항체. IHC 및 ELISA에 적합하며 인간 및 비인간 영장류 시료 반응성. 단백질 A/G로 정제된 동결건조 형태로 제공. PBS와 5% 트레할로스 완충액에 재구성 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | 8–25 µg/mL |
| ELISA (Detection) | 0.1–0.4 µg/mL |
| ELISA (Capture) | 2–8 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 10827 |
| Immunogen | E. coli-derived recombinant human EGF |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2609813 |
Product Specific Information
In sandwich ELISAs, no cross-reactivity or interference is observed with recombinant mouse (rm) EGF, bovine FGF acidic, bovine FGF basic, recombinant human (rh) G-CSF, rhGM-CSF, rmGM-CSF, rhLIF, human PDGF, porcine PDGF, rhTGF‑alpha, hTGF-beta 1, pTGF-beta 1, rhTGF-beta 1, porcine TGF-beta 1.2, porcine TGF-beta 2, rhTNF-alpha, or rhTNF-beta.
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
Epidermal Growth Factor (EGF) binds to the EGF receptor (EGFR), a 170 kDa protein kinase, to initiate cellular signaling pathways. Upon activation, EGFR forms homo- or heterodimers with other family members, triggering distinct signaling cascades through recruitment of SH2-containing effector proteins.
EGF is widely expressed in kidney, cerebrum, prostate, and salivary glands, acting as a potent mitogenic factor. The phosphorylated receptor recruits adapter proteins such as GRB2, activating downstream cascades including RAS-RAF-MEK-ERK, PI3K-AKT, PLCγ-PKC, and STAT pathways.
Research suggests EGF also plays a role in NF-κB signaling activation. Mutations in the EGF gene are linked to hypomagnesemia type 4, and dysregulation is associated with certain cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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